Design of polyurea networks containing anticancer and anti?inflammatory drugs for dual drug delivery purposes

Naproxen (Nap), a non-steroidal anti-inflammatory drug, and 5-fluorouracil (5FU), an anticancer were easily incorporated into polyurea xerogel. Polyureas (PUr) synthesized by one pot reaction via sol–gel chemistry. Soft segments based on polyetheramine-PEO hard hexamethylene diisocyanate trimer (HDI). The final materials characterized Fourier transform infrared (FTIR) spectroscopy, small-angle X-ray scattering (SAXS), differential scanning calorimetry (DSC). Polyurea can assume many forms revealing its versatility in terms of produced shapes. In good agreement with FTIR, SAXS studies showed microphase separated structure arising from inter-hard-domain spacings, which remains unchanged after incorporation the drugs. DSC analysis demonstrated that PEO chain mobility was poorly affected drugs due to solvation through network. water uptake amount drug released agree well, playing important role for controlled Nap 5FU release. This work opens positive perspectives ocular delivery wound management, easy processability xerogel, has high feasibility be moldable as pharmaceutical devices contact lenses transdermal patches purposes containing distinct therapeutic agents.